Cholera Toxin

An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.

Also Known As:

Cholera Enterotoxin CT; Cholera Exotoxin; Cholera Toxin A Subunit; Cholera Toxin B Subunit; Procholeragenoid; Enterotoxin CT, Cholera; Exotoxin, Cholera; Toxin A, Cholera; Toxin B, Cholera; Toxin, Cholera; Cholera Toxin A; Cholera Toxin B; Cholera Toxin Protomer A; Cholera Toxin Protomer B; Cholera Toxin Subunit A; Cholera Toxin Subunit B; Choleragen; Choleragenoid

Pharmalogical Action Categories:

Adjuvants, Immunologic
Poisons

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Glycosyltransferases: 784
      - Pentosyltransferases
        ADP Ribose Transferases: 198
        Cholera Toxin: 1392
Biological Factors: 2472
- Biological Toxins: 20
  - Enterotoxins: 2431
    - Cholera Toxin: 1392
  - Bacterial Toxins: 814
    - Cholera Toxin: 1392

Julie E Heggelund Selected Research

Julie E Heggelund Research Topics

Disease

Drug/Important Bio-Agent (IBA)